NeuroTechnology Studio

Technology Themes

The NeuroTechnology Studio will provide individual investigators access to advanced instrumentation, tools and expert support for studying the nervous system.  Technology themes are denoted below. Science and Technology Advisory Committees are being established to help prioritize equipment purchases. To date, one such Committee has been established—the Imaging Advisory Committee.

 

Equipment purchases will proceed over a 3-year period. The Studio will located in the BWH Building for Transformative Medicine, with its primary location on BTM—7th floor (soon to be under construction) and certain equipment housed on BTM— 9th and 10th floors.  As equipment is purchased and installed, training sessions will be scheduled.

 

For more information about equipment, training and usage, please contact: Dr. Lai Ding, Senior Imaging Scientist—NeuroTechnology Studio (LDing@bwh.harvard.edu).

 

The NeuroTechnology Studio’s Technology Themes include the following:

 

Advanced Microscopy and Imaging— Captures images and generates data about the nervous system, including assessing the activity of single cells and specific molecules to whole brain network analysis.The Studio has two major pieces of imaging equipment that has been installed— the GE IN Cell Analyzer 2200 (widefield high-content imaging system) and Zeiss LSM880 + AiryScan confocal/super-resolution microscope. Click here for access and training. A Leica RM2125 Rotary Microtome is also available for use.

 

A NeuroTech Imaging Advisory Committee is in place to ascertain overall priorities as well as which instruments and platforms are likely to have the biggest impact on our community. Committee membership is listed below.

 

Nathalie Agar
Oleg Butovsky
Ulf Dettmer
Vikram Khurana
Sean Lawler
Keith Ligon
Roni Nowarski
Tracy Young-Pearse
Stelios Smirnakis
Khalid Shah

 

DNA Sequencing, Gene Expression and Profiling Instruments— Provide sensitive measures of DNA, RNA, proteins and chemicals present in patient samples and help discern very precise profiles of inherited and other key disease characteristics.

 

Analytical Instruments—A range of instruments to help investigators understand the detailed characteristics of individual patients and their particular disease expression.

 

Medicinal Chemistry and Chemical Probes— Establishing a chemistry platform with the aim to accelerate the time it takes to develop, test and deploy drug-like small molecules for use as research tools or experimental treatments.

 

Informatics—Providing critical computational resources to store and analyze data that emerges from all the NeuroTechnology platforms, and to share the data widely.

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