Collaborative Drug Discovery Projects
We collaborate with world-renowned biologists and endeavor to transform their discoveries in neuroscience into opportunities for drug discovery. Brief descriptions of current medicinal chemistry projects and the respective academic biologist collaborator are outlined below:
Lead Optimization Projects:
In the hit-to-lead phase, preliminary SAR has been established, but a number of issues will be identified with the compounds that typically include: physicochemical (e.g., solubility, stability); pharmacokinetic (e.g., oral exposure, brain penetration); toxicity liabilities; and patentability. The goal is to further optimize and identify compounds with oral efficacy and safety in disease relevant models. Significant fine-tuning of properties may require intensive medicinal chemistry and compound evaluation before a clinical candidate can be identified.