NeuroTechnology Studio Publications

The following is a list of recent papers that include data produced using the Studio’s resources:

2021:

Elife2021 Jul 6;10:e64819.

Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo

Charlene Guillot, Yannis Djeffal, Arthur Michaut, Brian Rabe, Olivier Pourquié

Proc Natl Acad Sci U S A  2021 Jul 13;118(28):e2022960118.

Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro

Ziad Al Tanoury, John F Zimmerman, Jyoti Rao, Daniel Sieiro, Harold M McNamara, Thomas Cherrier, Alejandra Rodríguez-delaRosa, Aurore Hick-Colin, Fanny Bousson, Charlotte Fugier-Schmucker, Fabio Marchiano, Bianca Habermann, Jérome Chal, Alexander P Nesmith, Svetlana Gapon, Erica Wagner, Vandana A Gupta, Rhonda Bassel-Duby, Eric N Olson, Adam E Cohen, Kevin Kit Parker, Olivier Pourquié 

Cell Rep2021 Jul 6;36(1):109333.

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease

Luis Fonseca-Ornelas, Thibault Viennet, Matteo Rovere, Haiyang Jiang, Lei Liu, Silke Nuber, Maria Ericsson, Haribabu Arthanari, Dennis J Selkoe 

Hum Mol Genet2021 Jul 12;ddab188.

Excess membrane binding of monomeric alpha-, beta-, and gamma-synuclein is invariably associated with inclusion formation and toxicity

Tae-Eun Kim, Andrew J Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam, Saranna Fanning, Dennis Selkoe, Ulf Dettmer 

Nat Med2021 Jul;27(7):1212-1222.

Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

Benjamin M Scott , Cristina Gutiérrez-Vázquez , Liliana M Sanmarco  , Jessica A da Silva Pereira, Zhaorong Li  , Agustín Plasencia  , Patrick Hewson, Laura M Cox, Madelynn O’Brien, Steven K Chen, Pedro M Moraes-Vieira, Belinda S W Chang, Sergio G Peisajovich , Francisco J Quintana

PLoS Pathog  2021 May 6;17(5):e1009557.

Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection

Tiffany LinDaisy QuellierJeffrey LambTiphaine VoisinPankaj BaralFelix BockAlfrun SchönbergRossen MirchevGerald PierIsaac ChiuMihaela Gadjeva 

Proc Natl Acad Sci 2021 May 11;118(19):e2016146118

Reversed-engineered human alveolar lung-on-a-chip model

Di Huang, Tingting Liu, Junlong Liao, Sushila Maharjan, Xin Xie, Montserrat Pérez, Ingrid Anaya, Shiwei Wang, Alan Tirado Mayer, Zhixin Kang, Weijia Kong, Valerio Luca Mainardi, Carlos Ezio Garciamendez-Mijares, Germán García Martínez, Matteo Moretti, Weijia Zhang, Zhongze Gu, Amir M Ghaemmaghami, Yu Shrike Zhang

Science 2021 Apr 23;372(6540):eabf1230.

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Iain C Clark, Cristina Gutiérrez-Vázquez, Michael A Wheeler, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M Sanmarco, Lydia Guo, Manon Blain, Stephanie E J Zandee, Chun-Cheih Chao, Katelyn V Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W Shultis, Yasmin Salem, Emily C Tjon, Pedro H Fonseca-Castro, Davis M Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R Abate, Douglas L Rosene, Kevin J Hodgetts Marco Prinz, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nature  2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6.

Gut-licensed IFNγ + NK cells drive LAMP1 + TRAIL + anti-inflammatory astrocytes

Liliana M Sanmarco, Michael A Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V Batterman, Giulia Scalisi, Stephanie E J Zandee, Evelyn S Heck, Moneera Alsuwailm, Douglas L Rosene, Burkhard Becher, Isaac M Chiu, Alexandre Prat, Francisco J Quintana

Mov Disord 2021 Feb;36(2):348-359.doi: 10.1002/mds.28346. Epub 2020 Oct 26.

Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity

Gary P H Ho Nagendran Ramalingam Thibaut Imberdis Erin C Wilkie Ulf Dettmer Dennis J Selkoe 

Ann Neurol 2021 Jan;89(1):74-90. doi: 10.1002/ana.25920. Epub 2020 Oct 23.

A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice

Silke Nuber, Alice Y Nam, Molly M Rajsombath , Haley Cirka , Xiaoping Hronowski , Junmin Wang , Kevin Hodgetts , Liubov S Kalinichenko , Christian P Müller , Vera Lambrecht , Jürgen Winkler , Andreas Weihofen , Thibaut Imberdis , Ulf Dettmer , Saranna Fanning , Dennis J Selkoe 

2020:

Mov Disord  2020 May;35(5):760-773.  doi: 10.1002/mds.27994. Epub 2020 Feb 8.

Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

Anwesha Sanyal , Mark P DeAndrade , Hailey S Novis , Steven Lin , Jianjun Chang, Nathalie Lengacher , Julianna J Tomlinson , Malú G Tansey , Matthew J LaVoie 

Nature  2020 Feb;578(7796):593-599. doi: 10.1038/s41586-020-1999-0. Epub 2020 Feb 12.

MAFG-driven astrocytes promote CNS inflammation

Michael A Wheeler, Iain C Clark, Emily C Tjon, Zhaorong Li, Stephanie E J Zandee, Charles P Couturier, Brianna R Watson, Giulia Scalisi, Sarah Alkwai, Veit Rothhammer, Assaf Rotem, John A Heyman, Shravan Thaploo, Liliana M Sanmarco, Jiannis Ragoussis, David A Weitz , Kevin Petrecca, Jeffrey R Moffitt, Burkhard Becher, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nature Neuroscience volume 23, pages939–951(2020)

AHR is a Zika virus host factor and a candidate target for antiviral therapy

Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F. Torti, Michael A. Wheeler, Zhaorong Li, Leonardo Romorini, María S. Rodriguez Varela, Veit Rothhammer, Andreia Barroso, Emily C. Tjon, Liliana M. Sanmarco, Maisa C. Takenaka, Seyed Mohamad Sadegh Modaresi, Cristina Gutiérrez-Vázquez, Nágela Ghabdan Zanluqui, Nilton Barreto dos Santos, Carolina Demarchi Munhoz, Zhongyan Wang, Elsa B. Damonte, David Sherr, Lee Gehrke, Jean Pierre Schatzmann Peron, Cybele C. Garcia & Francisco J. Quintana

Biofabrication  10 November 2020  https://doi.org/10.1088/1758-5090/abc1be

Toward a Neurospheroid Niche Model: Optimizing Embedded 3D Bioprinting for Fabrication of Neurospheroid Brain-like Co-culture Constructs

Yi-Chen Li, Yasamin Jodat, Roya Samanipour, Giulio Zorzi, Kai Zhu, Minoru Hirano, Karen Chang, Adnan Arnaout, Shabir Hassan, Navneet Matharu, Ali Khademhosseini, Mina Hoorfar, Su Ryon Shin.

Small. 23 October 2020 https://doi.org/10.1002/smll.202004258

A Heart-Breast Cancer-on-a-Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

Junmin Lee, Shreya Mehrotra, Elaheh Zare-Eelanjegh, Raquel Rodrigues, Alireza Akbarinejad, David Ge, Luca Amato, Kiavash Kiaee, YongCong Fang, Aliza Rosenkranz, Wendy Keung, Biman B. Mandal, Ronald A Li, Ting Zhang, HeaYeon Lee, Mehmet Remzi Dokmeci, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin.

Adv Sci (Weinh) 2020 Jan 10;7(5):1901878. doi: 10.1002/advs.201901878. eCollection 2020 Mar.

A 3D-Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction

Yasamin A Jodat , Kiavash Kiaee , Daniel Vela Jarquin , Rosakaren Ludivina De la Garza Hernández 1, Ting Wang , Sudeep Joshi , Zahra Rezaei , Bruna Alice Gomes de Melo , David Ge , Manu S Mannoor , Su Ryon Shin 

Dev Cell  2020 Feb 24;52(4):525-540.e5. doi: 10.1016/j.devcel.2020.01.026.

Cellular Heterogeneity and Lineage Restriction during Mouse Digit Tip Regeneration at Single-Cell Resolution

Gemma L Johnson, Erick J Masias, Jessica A Lehoczky 

Nat Commun  2020 Mar 9;11(1):1267. doi: 10.1038/s41467-020-14997-4.

Complexation-inducedresolution enhancement of 3D-printed hydrogel constructs

Jiaxing Gong , Carl C L Schuurmans , Anne Metje van Genderen , Xia Cao , Wanlu Li , Feng Cheng , Jacqueline Jialu He , Arturo López , Valentin Huerta , Jennifer Manríquez , Ruiquan Li , Hongbin Li , Clément Delavaux , Shikha Sebastian , Pamela E Capendale , Huiming Wang , Jingwei Xie , Mengfei Yu , Rosalinde Masereeuw , Tina Vermonden , Yu Shrike Zhang 

DEVELOPMENT  2020 Jun26; 14(12):dev18344. doi: 10.1242

Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro

Ziad Al Tanoury, Jyoti Rao, Olivier Tassy, Bénédicte Gobert, Svetlana Gapon, Jean-Marie Garnier, Erica Wagner, Aurore Hick, Arielle Hall, Emanuela Gussoni, Olivier Pourquié

Alzheimers Res Ther. 2020 Jan 13;12(1):12

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice.

Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O’Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA

iScience  2020 Aug 21;23(8):101420. doi: 10.1016/j.isci.2020.101420. Epub 2020 Jul 29.

Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism

Ailiang Zeng , Zhiyun Wei , Rosalia Rabinovsky , Hyun Jung Jun , Rachid El Fatimy , Evgeny Deforzh , Ramil Arora , Yizheng Yao , Shun Yao , Wei Yan , Erik J Uhlmann , Alain Charest , Yongping You , Anna M Krichevsky 

Cell Rep. 2020 Feb 18;30(7):2065-2074.e4. doi: 10.1016/j.celrep.2020.01.073. PMID: 32075753

Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.

Lucero R, Zappulli V, Sammarco A, Murillo OD, Cheah PS, Srinivasan S, Tai E, Ting DT, Wei Z, Roth ME, Laurent LC, Krichevsky AM, Breakefield XO, Milosavljevic A. 

Methods  2020 Apr 8;S1046-2023(20)30047-5. doi: 10.1016/j.ymeth.2020.04.003. 

Investigating lymphangiogenesis in a sacrificially bioprinted volumetric model of breast tumor tissue

Tingting Liu , Qiong Liu , Ingrid Anaya , Di Huang , Weijia Kong , Luis S Mille , Yu Shrike Zhang 

Front Neurosci  2020 May 15;14:442.  doi: 10.3389/fnins.2020.00442. eCollection 2020.

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

Anwesha Sanyal , Hailey S Novis , Emile Gasser , Steven Lin , Matthew J LaVoie 

Adv Funct Mater  2020 Mar 17;30(12):1907436. doi: 10.1002/adfm.201907436. Epub 2020 Jan 20.

Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium-on-a-Chip Application

Shreya Mehrotra , Bruna A G de Melo , Minoru Hirano , Wendy Keung , Ronald A Li , Biman B Mandal , Su Ryon Shin 

J Am Soc Nephrol  2020 Jul;31(7):1479-1495.  doi: 10.1681/ASN.2019101032. Epub 2020 Jun 15.

Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

Di Feng, Mukesh Kumar, Jan Muntel , Susan B Gurley , Gabriel Birrane , Isaac E Stillman , Lai Ding, Minxian Wang , Saima Ahmed , Johannes Schlondorff , Seth L Alper , Tom Ferrante , Susan L Marquez , Carlos F Ng, Richard Novak , Donald E Ingber , Hanno Steen , Martin R Pollak 

Acta Neuropathol  2020 Mar;139(3):503-526. doi: 10.1007/s00401-019-02114-9. Epub 2019 Dec 18.

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Grant T Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C Hall , Lai Ding , Alexandra DeSousa , Matthew P Frosch , John Collinge , David A Harris, Michael S Perkinton, Tara L Spires-Jones, Tracy L Young-Pearse, Andrew Billinton, Dominic M Walsh

2019:

Cell  2019 Dec 12;179(7):1483-1498.e22. doi: 10.1016/j.cell.2019.11.016. Epub 2019 Dec 5.

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A Wheeler, Emily C Tjon, Stephanie E J Zandee, Manon Blain, Kalil Alves de Lima, Maisa C Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M Sanmarco, Davis M Borucki, Gabriel Z Lipof, Sunia A Trauger, Clary B Clish, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nat Neurosci 2019 May;22(5):729-740. doi: 10.1038/s41593-019-0370-y. Epub 2019 Apr 8.

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Maisa C Takenaka, Galina Gabriely, Veit Rothhammer, Ivan D Mascanfroni, Michael A Wheeler, Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Jessica Kenison, Emily C Tjon, Andreia Barroso, Tyler Vandeventer, Kalil Alves de Lima, Sonja Rothweiler, Lior Mayo, Soufiene Ghannam, Stephanie Zandee, Luke Healy, David Sherr, Mauricio F Farez , Alexandre Prat , Jack Antel, David A Reardon, Hailei Zhang, Simon C Robson, Gad Getz, Howard L Weiner, Francisco J Quintana

Cell 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17.

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation

Michael A Wheeler, Merja Jaronen, Ruxandra Covacu, Stephanie E J Zandee, Giulia Scalisi, Veit Rothhammer, Emily C Tjon, Chun-Cheih Chao, Jessica E Kenison, Manon Blain, Vijayaraghava T S Rao, Patrick Hewson, Andreia Barroso, Cristina Gutiérrez-Vázquez, Alexandre Prat, Jack P Antel, Russ Hauser, Francisco J Quintana

Last updated 04/20/21
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