The following is a list of recent papers that include data produced using the Studio’s resources:
2021:
Adv Mater 2021 Oct 5;e2107038.
Digital Light Processing Based Bioprinting with Composable Gradients
Mian Wang, Wanlu Li, Luis S Mille, Terry Ching, Zeyu Luo, Guosheng Tang, Carlos Ezio Garciamendez, Ami Lesha, Michinao Hashimoto, Yu Shrike Zhang
Sci Adv 2021 Oct 29;7(44):eabk2775.
Eun-Bee Choi, Munender Vodnala, Madeleine Zerbato, Jianing Wang, Jaclyn J Ho, Carla Inouye, Lai Ding, Yick W Fong
Alzheimers Dement 2021 Sep 22. doi: 10.1002/alz.12457.
An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma
Lei Liu, Hyunchang Kwak, Trebor L Lawton, Shan-Xue Jin , Angela L Meunier , Yifan Dang , Beth Ostaszewski , Alison C Pietras, Andrew M Stern, Dennis J Selkoe
Neuron 2021 Aug 26;S0896-6273(21)00578-X.
Valentina N Lagomarsino, Richard V Pearse 2nd, Lei Liu, Yi-Chen Hsieh, Marty A Fernandez, Elizabeth A Vinton, Daniel Paull, Daniel Felsky, Shinya Tasaki, Chris Gaiteri, Badri Vardarajan, Hyo Lee, Christina R Muratore, Courtney R Benoit, Vicky Chou, Seeley B Fancher, Amy He, Julie P Merchant, Duc M Duong, Hector Martinez, Monica Zhou, Fatmata Bah, Maria A Vicent, Jonathan M S Stricker, Jishu Xu, Eric B Dammer, Allan I Levey, Lori B Chibnik, Vilas Menon, Nicholas T Seyfried, Philip L De Jager, Scott Noggle, Dennis J Selkoe, David A Bennett, Tracy L Young-Pearse
Nat Commun 2021 Aug 13;12(1):4907.
PD-L1 + and XCR1 + dendritic cells are region-specific regulators of gut homeostasis
Thais G Moreira, Davide Mangani, Laura M Cox, Jeffrey Leibowitz, Eduardo L C Lobo, Mariana A Oliveira, Christian D Gauthier, Brenda N Nakagaki, Valerie Willocq, Anya Song, Lydia Guo, David C A Lima, Gopal Murugaiyan, Oleg Butovsky, Galina Gabriely, Ana C Anderson, Rafael M Rezende, Ana Maria C Faria, Howard L Weiner
Bio Protoc 2021 Aug 5;11(15):e4102.
Isolation of Nuclei from Mouse Dorsal Root Ganglia for Single-nucleus Genomics
Lite Yang, Ivan Tochitsky, Clifford J Woolf, William Renthal
Proc Natl Acad Sci USA 2021 Jul 13;118(28):e2022960118.
Ziad Al Tanoury, John F Zimmerman, Jyoti Rao, Daniel Sieiro, Harold M McNamara, Thomas Cherrier, Alejandra Rodríguez-delaRosa, Aurore Hick-Colin, Fanny Bousson, Charlotte Fugier-Schmucker, Fabio Marchiano, Bianca Habermann, Jérome Chal, Alexander P Nesmith, Svetlana Gapon, Erica Wagner, Vandana A Gupta, Rhonda Bassel-Duby, Eric N Olson, Adam E Cohen, Kevin Kit Parker, Olivier Pourquié
Elife2021 Jul 6;10:e64819.
Charlene Guillot, Yannis Djeffal, Arthur Michaut, Brian Rabe, Olivier Pourquié
Proc Natl Acad Sci U S A 2021 Jul 13;118(28):e2022960118.
Ziad Al Tanoury, John F Zimmerman, Jyoti Rao, Daniel Sieiro, Harold M McNamara, Thomas Cherrier, Alejandra Rodríguez-delaRosa, Aurore Hick-Colin, Fanny Bousson, Charlotte Fugier-Schmucker, Fabio Marchiano, Bianca Habermann, Jérome Chal, Alexander P Nesmith, Svetlana Gapon, Erica Wagner, Vandana A Gupta, Rhonda Bassel-Duby, Eric N Olson, Adam E Cohen, Kevin Kit Parker, Olivier Pourquié
Cell Rep2021 Jul 6;36(1):109333.
Luis Fonseca-Ornelas, Thibault Viennet, Matteo Rovere, Haiyang Jiang, Lei Liu, Silke Nuber, Maria Ericsson, Haribabu Arthanari, Dennis J Selkoe
Hum Mol Genet2021 Jul 12;ddab188.
Tae-Eun Kim, Andrew J Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam, Saranna Fanning, Dennis Selkoe, Ulf Dettmer
Nat Med2021 Jul;27(7):1212-1222.
Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease
Benjamin M Scott , Cristina Gutiérrez-Vázquez , Liliana M Sanmarco , Jessica A da Silva Pereira, Zhaorong Li , Agustín Plasencia , Patrick Hewson, Laura M Cox, Madelynn O’Brien, Steven K Chen, Pedro M Moraes-Vieira, Belinda S W Chang, Sergio G Peisajovich , Francisco J Quintana
PLoS Pathog 2021 May 6;17(5):e1009557.
Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection
Tiffany Lin, Daisy Quellier, Jeffrey Lamb, , Pankaj Baral, Felix Bock, , , Gerald Pier, Isaac Chiu, Mihaela Gadjeva
Proc Natl Acad Sci 2021 May 11;118(19):e2016146118
Reversed-engineered human alveolar lung-on-a-chip model
Di Huang, Tingting Liu, Junlong Liao, Sushila Maharjan, Xin Xie, Montserrat Pérez, Ingrid Anaya, Shiwei Wang, Alan Tirado Mayer, Zhixin Kang, Weijia Kong, Valerio Luca Mainardi, Carlos Ezio Garciamendez-Mijares, Germán García Martínez, Matteo Moretti, Weijia Zhang, Zhongze Gu, Amir M Ghaemmaghami, Yu Shrike Zhang
Science 2021 Apr 23;372(6540):eabf1230.
Barcoded viral tracing of single-cell interactions in central nervous system inflammation
Iain C Clark, Cristina Gutiérrez-Vázquez, Michael A Wheeler, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M Sanmarco, Lydia Guo, Manon Blain, Stephanie E J Zandee, Chun-Cheih Chao, Katelyn V Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W Shultis, Yasmin Salem, Emily C Tjon, Pedro H Fonseca-Castro, Davis M Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R Abate, Douglas L Rosene, Kevin J Hodgetts Marco Prinz, Jack P Antel, Alexandre Prat, Francisco J Quintana
Nature 2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6.
Gut-licensed IFNγ + NK cells drive LAMP1 + TRAIL + anti-inflammatory astrocytes
Liliana M Sanmarco, Michael A Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V Batterman, Giulia Scalisi, Stephanie E J Zandee, Evelyn S Heck, Moneera Alsuwailm, Douglas L Rosene, Burkhard Becher, Isaac M Chiu, Alexandre Prat, Francisco J Quintana
Mov Disord 2021 Feb;36(2):348-359.doi: 10.1002/mds.28346. Epub 2020 Oct 26.
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity
Ann Neurol 2021 Jan;89(1):74-90. doi: 10.1002/ana.25920. Epub 2020 Oct 23.
Silke Nuber, Alice Y Nam, Molly M Rajsombath , Haley Cirka , Xiaoping Hronowski , Junmin Wang , Kevin Hodgetts , Liubov S Kalinichenko , Christian P Müller , Vera Lambrecht , Jürgen Winkler , Andreas Weihofen , Thibaut Imberdis , Ulf Dettmer , Saranna Fanning , Dennis J Selkoe
2020:
Mov Disord 2020 May;35(5):760-773. doi: 10.1002/mds.27994. Epub 2020 Feb 8.
Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition
Anwesha Sanyal , Mark P DeAndrade , Hailey S Novis , Steven Lin , Jianjun Chang, Nathalie Lengacher , Julianna J Tomlinson , Malú G Tansey , Matthew J LaVoie
Nature 2020 Feb;578(7796):593-599. doi: 10.1038/s41586-020-1999-0. Epub 2020 Feb 12.
MAFG-driven astrocytes promote CNS inflammation
Michael A Wheeler, Iain C Clark, Emily C Tjon, Zhaorong Li, Stephanie E J Zandee, Charles P Couturier, Brianna R Watson, Giulia Scalisi, Sarah Alkwai, Veit Rothhammer, Assaf Rotem, John A Heyman, Shravan Thaploo, Liliana M Sanmarco, Jiannis Ragoussis, David A Weitz , Kevin Petrecca, Jeffrey R Moffitt, Burkhard Becher, Jack P Antel, Alexandre Prat, Francisco J Quintana
Nature Neuroscience volume 23, pages939–951(2020)
AHR is a Zika virus host factor and a candidate target for antiviral therapy
Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F. Torti, Michael A. Wheeler, Zhaorong Li, Leonardo Romorini, María S. Rodriguez Varela, Veit Rothhammer, Andreia Barroso, Emily C. Tjon, Liliana M. Sanmarco, Maisa C. Takenaka, Seyed Mohamad Sadegh Modaresi, Cristina Gutiérrez-Vázquez, Nágela Ghabdan Zanluqui, Nilton Barreto dos Santos, Carolina Demarchi Munhoz, Zhongyan Wang, Elsa B. Damonte, David Sherr, Lee Gehrke, Jean Pierre Schatzmann Peron, Cybele C. Garcia & Francisco J. Quintana
Biofabrication 10 November 2020 https://doi.org/10.1088/1758-5090/abc1be
Yi-Chen Li, Yasamin Jodat, Roya Samanipour, Giulio Zorzi, Kai Zhu, Minoru Hirano, Karen Chang, Adnan Arnaout, Shabir Hassan, Navneet Matharu, Ali Khademhosseini, Mina Hoorfar, Su Ryon Shin.
Small. 23 October 2020 https://doi.org/10.1002/smll.202004258
Junmin Lee, Shreya Mehrotra, Elaheh Zare-Eelanjegh, Raquel Rodrigues, Alireza Akbarinejad, David Ge, Luca Amato, Kiavash Kiaee, YongCong Fang, Aliza Rosenkranz, Wendy Keung, Biman B. Mandal, Ronald A Li, Ting Zhang, HeaYeon Lee, Mehmet Remzi Dokmeci, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin.
Adv Sci (Weinh) 2020 Jan 10;7(5):1901878. doi: 10.1002/advs.201901878. eCollection 2020 Mar.
A 3D-Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction
Yasamin A Jodat , Kiavash Kiaee , Daniel Vela Jarquin , Rosakaren Ludivina De la Garza Hernández 1, Ting Wang , Sudeep Joshi , Zahra Rezaei , Bruna Alice Gomes de Melo , David Ge , Manu S Mannoor , Su Ryon Shin
Dev Cell 2020 Feb 24;52(4):525-540.e5. doi: 10.1016/j.devcel.2020.01.026.
Gemma L Johnson, Erick J Masias, Jessica A Lehoczky
Nat Commun 2020 Mar 9;11(1):1267. doi: 10.1038/s41467-020-14997-4.
Complexation-inducedresolution enhancement of 3D-printed hydrogel constructs
Jiaxing Gong , Carl C L Schuurmans , Anne Metje van Genderen , Xia Cao , Wanlu Li , Feng Cheng , Jacqueline Jialu He , Arturo López , Valentin Huerta , Jennifer Manríquez , Ruiquan Li , Hongbin Li , Clément Delavaux , Shikha Sebastian , Pamela E Capendale , Huiming Wang , Jingwei Xie , Mengfei Yu , Rosalinde Masereeuw , Tina Vermonden , Yu Shrike Zhang
DEVELOPMENT 2020 Jun26; 14(12):dev18344. doi: 10.1242
Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro
Ziad Al Tanoury, Jyoti Rao, Olivier Tassy, Bénédicte Gobert, Svetlana Gapon, Jean-Marie Garnier, Erica Wagner, Aurore Hick, Arielle Hall, Emanuela Gussoni, Olivier Pourquié
Alzheimers Res Ther. 2020 Jan 13;12(1):12
Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O’Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA
iScience 2020 Aug 21;23(8):101420. doi: 10.1016/j.isci.2020.101420. Epub 2020 Jul 29.
Ailiang Zeng , Zhiyun Wei , Rosalia Rabinovsky , Hyun Jung Jun , Rachid El Fatimy , Evgeny Deforzh , Ramil Arora , Yizheng Yao , Shun Yao , Wei Yan , Erik J Uhlmann , Alain Charest , Yongping You , Anna M Krichevsky
Cell Rep. 2020 Feb 18;30(7):2065-2074.e4. doi: 10.1016/j.celrep.2020.01.073. PMID: 32075753
Lucero R, Zappulli V, Sammarco A, Murillo OD, Cheah PS, Srinivasan S, Tai E, Ting DT, Wei Z, Roth ME, Laurent LC, Krichevsky AM, Breakefield XO, Milosavljevic A.
Methods 2020 Apr 8;S1046-2023(20)30047-5. doi: 10.1016/j.ymeth.2020.04.003.
Tingting Liu , Qiong Liu , Ingrid Anaya , Di Huang , Weijia Kong , Luis S Mille , Yu Shrike Zhang
Front Neurosci 2020 May 15;14:442. doi: 10.3389/fnins.2020.00442. eCollection 2020.
Anwesha Sanyal , Hailey S Novis , Emile Gasser , Steven Lin , Matthew J LaVoie
Adv Funct Mater 2020 Mar 17;30(12):1907436. doi: 10.1002/adfm.201907436. Epub 2020 Jan 20.
Shreya Mehrotra , Bruna A G de Melo , Minoru Hirano , Wendy Keung , Ronald A Li , Biman B Mandal , Su Ryon Shin
J Am Soc Nephrol 2020 Jul;31(7):1479-1495. doi: 10.1681/ASN.2019101032. Epub 2020 Jun 15.
Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis
Di Feng, Mukesh Kumar, Jan Muntel , Susan B Gurley , Gabriel Birrane , Isaac E Stillman , Lai Ding, Minxian Wang , Saima Ahmed , Johannes Schlondorff , Seth L Alper , Tom Ferrante , Susan L Marquez , Carlos F Ng, Richard Novak , Donald E Ingber , Hanno Steen , Martin R Pollak
Acta Neuropathol 2020 Mar;139(3):503-526. doi: 10.1007/s00401-019-02114-9. Epub 2019 Dec 18.
Grant T Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C Hall , Lai Ding , Alexandra DeSousa , Matthew P Frosch , John Collinge , David A Harris, Michael S Perkinton, Tara L Spires-Jones, Tracy L Young-Pearse, Andrew Billinton, Dominic M Walsh
Int J Mol Sci 2020 Jul 22;21(15):5193. doi: 10.3390/ijms21155193.
Elizabeth Terry-Kantor , Arati Tripathi , Thibaut Imberdis , Zachary M LaVoie , Gary P H Ho , Dennis Selkoe , Saranna Fanning , Nagendran Ramalingam , Ulf Dettmer
Mov Disord 2020 Oct 26. doi: 10.1002/mds.28346. Online ahead of print.
Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity
Gary P H Ho , Nagendran Ramalingam , Thibaut Imberdis , Erin C Wilkie , Ulf Dettmer , Dennis J Selkoe
2019:
Cell 2019 Dec 12;179(7):1483-1498.e22. doi: 10.1016/j.cell.2019.11.016. Epub 2019 Dec 5.
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A Wheeler, Emily C Tjon, Stephanie E J Zandee, Manon Blain, Kalil Alves de Lima, Maisa C Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M Sanmarco, Davis M Borucki, Gabriel Z Lipof, Sunia A Trauger, Clary B Clish, Jack P Antel, Alexandre Prat, Francisco J Quintana
Nat Neurosci 2019 May;22(5):729-740. doi: 10.1038/s41593-019-0370-y. Epub 2019 Apr 8.
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
Maisa C Takenaka, Galina Gabriely, Veit Rothhammer, Ivan D Mascanfroni, Michael A Wheeler, Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Jessica Kenison, Emily C Tjon, Andreia Barroso, Tyler Vandeventer, Kalil Alves de Lima, Sonja Rothweiler, Lior Mayo, Soufiene Ghannam, Stephanie Zandee, Luke Healy, David Sherr, Mauricio F Farez , Alexandre Prat , Jack Antel, David A Reardon, Hailei Zhang, Simon C Robson, Gad Getz, Howard L Weiner, Francisco J Quintana
Cell 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17.
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation
Michael A Wheeler, Merja Jaronen, Ruxandra Covacu, Stephanie E J Zandee, Giulia Scalisi, Veit Rothhammer, Emily C Tjon, Chun-Cheih Chao, Jessica E Kenison, Manon Blain, Vijayaraghava T S Rao, Patrick Hewson, Andreia Barroso, Cristina Gutiérrez-Vázquez, Alexandre Prat, Jack P Antel, Russ Hauser, Francisco J Quintana
2018:
Transl Psychiatry 2018 Nov 8;8(1):245.
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression
Priya Srikanth , Valentina N Lagomarsino, Richard V Pearse , Meichen Liao, Sulagna Ghosh, Ralda Nehme, Nicholas Seyfried, Kevin Eggan, Tracy L Young-Pearse
Nat Commun 2018 Nov 1;9(1):4578.
Acute microglia ablation induces neurodegeneration in the somatosensory system
Stephen J Rubino, Lior Mayo, Isabella Wimmer, Victoria Siedler, Florian Brunner, Simon Hametner, Asaf Madi, Amanda Lanser, Thais Moreira, Dustin Donnelly, Laura Cox, Rafael Machado Rezende, Oleg Butovsky, Hans Lassmann, Howard L Weiner
Acta Neuropathol 2018 Oct;136(4):537-555.
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways
Rachid El Fatimy, Shaomin Li, Zhicheng Chen, Tasnim Mushannen, Sree Gongala, Zhiyun Wei, Darrick T Balu, Rosalia Rabinovsky, Adam Cantlon, Abdallah Elkhal, Dennis J Selkoe, Kai C Sonntag, Dominic M Walsh, Anna M Krichevsky
EMBO Mol Med 2018 Sep;10(9):e8931.
Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β
Huixin Xu , Molly M Rajsombath , Pia Weikop , Dennis J Selkoe
Nat Commun 2018 Jul 11;9(1):2676.
An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N Lagomarsino, Tiernan T O’Malley, Wen Liu, Charles R Vanderburg, Matthew P Frosch, Tracy Young-Pearse, Dennis J Selkoe, Dominic M Walsh
Nat Commun 2018 Aug 8;9(1):3151
γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
Rafael M Rezende, Amanda J Lanser, Stephen Rubino, Chantal Kuhn, Nathaniel Skillin, Thais G Moreira, Shirong Liu, Galina Gabriely, Bruna A David, Gustavo B Menezes, Howard L Weiner